Dr. Jon Hyman

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advances in hip arthroscopy
advances in knee biosurgery

Medical News

New Cartilage Restoring Surgery trying to enter US Markets


DeNovo®ET Living Cartilage Implant

DeNovo NT (Natural Tissue) is now in use. For the latest, read more. 

DeNovo ET (Engineered Tissue) is still investigational, requiring FDA approval.

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 DeNovo ET, a scaffold-free, living cartilage implant, offers a one-step alternative to current cartilage repair. Designed to be offered as a product for the repair and regeneration of knee cartilage, DeNovo ET is applied to defects of the joint surface using a protein-based adhesive in a simple one-step procedure.  DeNovo ET is hyaline cartilage, displaying biochemical properties similar to those of articular cartilage found in young, healthy joints (1). Because cells used to produce DeNovo ET are derived from juvenile tissue, DeNovo ET is expected to heal and regenerate damaged joint cartilage more effectively than technologies that use adult cells. Pre-clinical testing has demonstrated the ability of DeNovo ET to integrate with native cartilage and bone while retaining its hyaline properties (2).  Read More...

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 A Phase I/II clinical trial for DeNovo ET is underway at three sites in the United States for the treatment of cartilage defects to restore joint function and to provide relief of knee pain. ISTO has partnered with Zimmer, Inc. to develop and commercialize Denovo ET.
  1. Adkisson HD, IV, Gillis MP, Davis E C, et al. In vitro generation of scaffold independent neocartilage.  Clin Orthop Rel Res 2001; 391S:S280-S294.
  2. Lu Y, Adkisson HD, Bogdanske JP, et al.  In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. J Knee Surg 2005; 18:31-42.

Read More...

Also in: Medical News

Aug 17, 2009 Pioneering Cartilage Restoration Surgery - DeNovo NT: Early in 2009, the 1st DeNovo natural tissue graft cartilage transplant in the Southeastern United States was performed by Jon Hyman, MD, at Emory-Adventist Hospital

Jul 18, 2009 Carlos Delago, Alex Rodriguez and Kurt Warner: hip surgery: Alex Rodriguez had arthroscopic hip surgery 3/9/09 and now Kurt Warner 3/18/09. Carlos Delgado has his hip scoped 5/19/09. The list just grows, and grows...

Jun 30, 2009 More Athletes Getting Hip Arthroscopy -Harvard trained surgeon: in 2009,more professional athletes have been undergoing arthroscopic hip surgery, Alex Rodriquez, Chase Utley, Kurt Warner...

Oct 8, 2008 New Cartilage Restoring Surgery trying to enter US Markets: DeNovo ET, a scaffold-free, living cartilage implant, offers a one-step alternative to current cartilage repair.
A Phase I/II clinical trial for DeNovo ET is underway at three sites in the United States

Sep 2, 2009 Newest Advances in Knee BioSurgery: We are busy trying to develop cartilage restoration technologies to prevent the knee from wearing out and needing prosthetic metal replacement. This article gives you the current update on what the future looks like for state-of-the-art knee surgery.

Aug 1, 2009 Ways to Preserve Your Joints: Here we present the latest 2009 perspectives on staying healthy and preserving your joints.


www.drjonhyman.com is the place where Atlanta's athletes come for cutting edge Sports Medicine news and information.Interact with other athletes, share tips and advice, or interact with Harvard trained physicians, with questions you may have related to sports medicine. We are not rendering medical care, but can point you to relevant information. All physician advisors and consultants to Atlanta's Athletes Online are Harvard trained doctors. This site is not affiliated with Harvard University.