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New Cartilage Restoring Surgery trying to enter US Markets


DeNovo®ET Living Cartilage Implant

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 DeNovo ET, a scaffold-free, living cartilage implant, offers a one-step alternative to current cartilage repair. Designed to be offered as a product for the repair and regeneration of knee cartilage, DeNovo ET is applied to defects of the joint surface using a protein-based adhesive in a simple one-step procedure.  DeNovo ET is hyaline cartilage, displaying biochemical properties similar to those of articular cartilage found in young, healthy joints (1). Because cells used to produce DeNovo ET are derived from juvenile tissue, DeNovo ET is expected to heal and regenerate damaged joint cartilage more effectively than technologies that use adult cells. Pre-clinical testing has demonstrated the ability of DeNovo ET to integrate with native cartilage and bone while retaining its hyaline properties (2).  Read More...

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 A Phase I/II clinical trial for DeNovo ET is underway at three sites in the United States for the treatment of cartilage defects to restore joint function and to provide relief of knee pain. ISTO has partnered with Zimmer, Inc. to develop and commercialize Denovo ET.
  1. Adkisson HD, IV, Gillis MP, Davis E C, et al. In vitro generation of scaffold independent neocartilage.  Clin Orthop Rel Res 2001; 391S:S280-S294.
  2. Lu Y, Adkisson HD, Bogdanske JP, et al.  In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. J Knee Surg 2005; 18:31-42.

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Also in: Medical News

Oct 8, 2008 New Cartilage Restoring Surgery trying to enter US Markets: DeNovo ET, a scaffold-free, living cartilage implant, offers a one-step alternative to current cartilage repair.
A Phase I/II clinical trial for DeNovo ET is underway at three sites in the United States

Jan 1, 2008 Ways to Preserve Your Joints: Here we present the latest 2008 perspectives on staying healthy and preserving your joints.

Aug 22, 2008 Hip Arthroscopy: Olympic impact and at home: Olympians are even getting it, but insurance carriers continue to deny care for the rest of us. One insurer, Kaiser Permanente, even issued a statement to it's doctors to stop referring patients to me because they didn't want to pay for hip arthroscopy. Coventry won't recognize the procedure, even though it's been a proven treatment for many years...

Aug 17, 2007 Hospital for Special Surgery Ranked No. 1 in USA: Hospital for Special Surgery Ranked (HSS) No. 1 Tops in the Nation in Orthopaedics by U.S. News & World Report 2007!
Read on to find out which Orthopaedic Surgeons in Atlanta trained at the Best Orthopaedic program in the Country...

Dec 30, 2007 More Athletes Getting Hip Arthroscopy: in 2008,another professional athlete undergoing arthroscopic hip surgery, professional basketball player Troy Hudson Golden State Warriors...

Jan 20, 2007 Newest Advances in Knee BioSurgery: We are busy trying to develop cartilage restoration technologies to prevent the knee from wearing out and needing prosthetic metal replacement. This article gives you the current update on what the future looks like for state-of-the-art knee surgery.


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